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Fig. 1 | BMC Clinical Pathology

Fig. 1

From: Differential expression of CK20, β-catenin, and MUC2/5AC/6 in Lynch syndrome and familial colorectal cancer type X

Fig. 1

β-catenin expression in a FCCTX carcinoma (a) and in a Lynch syndrome carcinoma (b): The invasive front of FCCTX carcinoma (a) with prominent nuclear labelling of the single, budding tumor cells (some are arrowed) and in most tumor cells sited in the more coherent group. This aberrant profile characterized 52% of the FCCTX cohort, but only 16% of the Lynch syndrome tumors. Note additionally the infiltrative quality of the invasive front of the tumor, another feature of FCCTX tumors [4]. The invasive front of a Lynch syndrome carcinoma (b) with normal staining pattern, i.e. labelling confined to the tumor cell membranes, specifically absence of nuclear labelling. Note the pushing quality of the invasive border (below) and absence of budding cells, additional features of Lynch syndrome carcinomas [4]

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BMC Clinical Pathology

ISSN: 1472-6890

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