Skip to main content

Table 9 Test-performance of the 5-type mRNA test and 13–14 types DNA tests in delayed triage and reflex testing of women with minor cytological lesions and CIN3+ as outcome

From: 5-type HPV mRNA versus 14-type HPV DNA test: test performance, over-diagnosis and overtreatment in triage of women with minor cervical lesions

Ref. Data collection Year publ. Country Study design Timing HPV test Length f-up (mo) Diagnosis HPV test N N HPV positive N Met for biopsy CIN3+
Sens. Spes. PPV NPV
6 July 2005– Dec. 2009 2013 Norway Case-series Delayed
triage
≤36 Repeat ASCUS/LSIL HC II
5 mRNA
2150
1543
1504
510
1 184
435
NR
7 Jan. 2004–
Dec. 2006
2011 Italy Head-to-head Reflex
testing
≤2 ASCUS/
LSIL
HC II
5 mRNA
795
755
614
204
377
132
NR
10 Jan. 2012–
Sept. 2012
2014 Norwaya Head-to-head Delayed
triage
≤33 Repeat
ASCUS/LSIL
COBAS
5 mRNA
281
281
92
37
65
26
100
75.0
77.8
91.6
6.2
11.5
100
99.6
11 Aug. 2005–
Jan. 2007
2008 UK Head-to-head Reflex
testing
Same day ≤ mild dyskaryosis HC II
5 mRNA
567
558
NR NRe 100
89.4
26.0
72.8
11.1
23.2
100
NR
12 Sept. 2007– Oct. 2009 2012 UK Head-to-head Reflex
Testing
Same
day
≤ mild dyskaryosis HC II
5 mRNA
670
641
526
272
NRe 100
80.9
NR 9.2
16.6
100
NR
16 NR 2010 Canada Head-to-head Reflex
testing
≤6 ASCUS/
LSIL
HC II
5 mRNA
781
781
619
328
NRe NR
A Jan. 2012– Sep. 2013   Norwaya Head-to-head Delayed
testing
≤33 Repeat
ASCUS/LSIL
COBAS
5 mRNA
564
564
171
105
105
77
100
100
80.0
85.2
13.9
16.3
100
100
  1. A Present study
  2. Sens Sensitivity; Spes. Specificity; PPV positive predictive value; NPV negative predictive value; NR Not reported; NRe Not relevant. All women had colposcopy regardless of HPV result
  3. aOnly solved cases are included in test-performance analysis